The kudo will be presented at the 21st Annual PGA Awards ceremony on Jan. 24 at the Hollywood Palladium.
Whedon is a producer, writer, director, and creator for TV series "Buffy the Vampire Slayer," "Angel," "Firefly," and "Dollhouse" with film scripts including "Buffy the Vampire Slayer," "Toy Story," "Alien Resurrection" and "Titan A.E." He's penned the comic book series "Fray" and created and produced Internet series "Dr. Horrible's Sing-Along-Blog."
"The Cabin in the Woods," a feature he co-wrote with Drew Goddard, is currently in post-production and will be released in 2011 by MGM.
Previous Vanguard Award recipients include George Lucas, James Cameron, John Lasseter, MySpace CEO and co-founder Chris DeWolfe and president and co-founder Tom Anderson, YouTube founders Chad Hurley, Steve Chen, and Will Wright.
"Joss Whedon has mastered the art of melding the newest technology with inspired storytelling, truly exemplifying the spirit of the Vanguard Award," said David Friendly and Laurence Mark, co-chairs of the PGA Awards.